Managers don't hire resumes, they hire people.  Sounds obvious, but do you really practice this?  Far too much emphasis is placed on resumes, which are really not that important. For the hiring manager, a resume is really a time management tool: no one gets hired from a resume. They use it to identify the most desirable candidates to interview, but what they really want isn't the best person who's looking - they want the best person, period!
The desirability and hiring risk of a candidate's profile varies by type: